Medical School:
Washington University
School of Medicine
St Louis, Missouri
Internal Medicine Residency:
University of Florida
Gainesville, Florida
Oncology-Hematology Fellowship:
Hematology and Oncology, University
of California Los Angeles (UCLA), Los Angeles, California
Specialty Training and Advanced Research, University of
California Los Angeles (UCLA), Los Angeles, California
Board Certifications:
Internal Medicine
Medical Oncology
Hematology
Dr. Sjak-Shie is board certified in Internal Medicine, Medical Oncology, and Hematology.
She has been involved in basic science, translational, and clinical research throughout her
career. As an assistant professor at UCLA, Cedars Sinai Medical
Center, she concentrated her research efforts on patients with
bone metastases and plasma cell dyscrasias. She joined
Arch Medical Services, Inc. in January 2002 where she hopes
to expand the available clinical trial portfolio to include
more research protocols on hematological malignancies.
Dr. Sjak-Shie has office hours at our St. Louis office located at 12855 N Forty Drive, Suite 200 and our Washington office located at 1351 Jefferson St., Suite 120.
N. N. Sjak-Shie, A. Mikail, H. Ma, T. Moss, R. A. Vescio, and J. R. Berenson. Frequent
detection of human herpesvirus-8 (HHV-8) in peripheral blood dendritic cells from patients
with plasma cell dyscrasias. Submitted.
H. J. Ma, N. N. Sjak-Shie, R. A. Vescio, M. Kaminsky, A. Mikail, M. Pold, K.
Parker, M Beksac, D. Belson, T. J. Moss, C. H. Wu, J. Zhou, L. Zhang, G. Chen, J. W. Said,
and J. R. Berenson. Human herpesvirus 8 ORF26 and ORF65 sequences from multiple myeloma
patients: A shared pattern not found in Kaposi's sarcoma or primary effusion lymphoma.
Clin. Cancer Res., Vol. 6: 4226-4233, 2000.
M. Pold, A. Pold, M. Hong, N. N. Sjak-Shie, R. A. Vescio, J. R. Berenson. Cloning
of the first invertebrate MAGE paralogue: An epitope that activates T-cells in humans is
highly conserved in evolution. Dev. Comp. Immunol., Vol. 24: 719-731, 2000.
N. N. Sjak-Shie, R. A. Vescio, and J. R. Berenson. HHV-8 infection and multiple
myeloma. J. Leukoc. Biol. Vol. 66: 357-360, 1999.
N. N. Sjak-Shie and E. M. Meyer. Effects of chronic nicotine and pilocarpine
administration on neocortical neuronal density and [H3] GABA uptake in nucleus basalis
lesioned rats. Brain Research, Vol. 624: 295-298, 1993.
N. N. Sjak-Shie, J. Scott, R. T. Watson, D. Wang, J. Burks, E. M. Meyer.
Cholinergic-peptide interactions in vivo: molecular to behavioral considerations. ICSU
Short Reports, Vol. 9: 119, 1989.
R. Lottenberg, N. N. Sjak-Shie, A. T. Fazleabas, and R. M. Roberts. Aprotinin
inhibits urokinase but not tissue plasminogen activator. Thrombosis Research, Vol. 49:
549-556, 1988.
Published Research Abstracts (peer reviewed)
M. H. Ma, M. J. Borad, J. Friedman, A. Glowalla, S. Manyak, C. Altamirano, Y. Tang, E.
Roussos, J. Neeser, M. Roy, H. Yang, N. N. Sjak-Shie, R. Vescio, and J. Berenson. Arsenic
trioxide-mediated growth inhibition and apoptosis in multiple myeloma cells correlated with
inhibition of nuclear factor (NF)-?B activity. Blood, Vol 98, Suppl. 1, 420a, 2001.
S. Manyak, S. Prakash, B. Waterman, M. Ma, C. Altamirano, Y. Tang, N. N. Sjak-Shie,
H. Yang, R. Vescio, and J. Berenson. A clinically relevant in vivo model for human multiple
myeloma in SCID mice. Blood, Vol 98, Suppl. 1, 3320a, 2001.
M. Ma, K. Parker, S. Manyak, C. Altamirano, Z. Wu, M. Borad, E. Roussos, J. Neeser,
A. Mikail, M. Frantzen, J. Adams, H. Yang, N. N. Sjak-Shie, R. Vescio, and J. Berenson.
Proteosome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma cells to
chemotherapeutic agents and overcomes chemo-resistance through inhibition of NF-?B pathway.
Blood, Vol 98, Suppl. 1, 1978a, 2001.
R. Vescio, N. N. Sjak-Shie, S. Manyak, H. Yang, and J. Berenson. Clarithromycin
(Biaxin) adds to the efficacy and toxicity of steroid therapy in multiple myeloma. Blood,
Vol 98, Suppl. 2, 5007a, 2001.
C. V Altamirano, J. Neeser, S. Manyak, Y. M. Tang, N. N. Sjak-Shie, J. Okopnik, H.
J. Ma, K. M. Parker, R. Vescio, and J. R. Berenson. Malignant Multiple Myeloma Cells
Expressing RANKL Induce the Formation of TRAP Positive Multinucleated Cells. Blood, Vol. 98,
Suppl.1, 2667a, 2001.
N. N. Sjak-Shie, S. J. Manyak, H. Ma, C. V. Altamirano, R. A. Vescio, and J. R.
Berenson. Clarithromycin adds to the efficacy of steroid therapy with/without thalidomide
in multiple myeloma: clinical and laboratory evidence. VIII International Multiple Myeloma
Workshop Abstract Book: 198, 2001.
C. V. Altamirano, H. Ma, K. M. Parker, J. vonTiechert, N. N. Sjak-Shie, R. A.
Vescio, and J. R. Berenson. Malignant multiple myeloma (MM) cells express RANKL a moderator
of osteoclast activation. VIII International Multiple Myeloma Workshop Abstract Book: 221,
2001.
M. Ma, C. V. Altamirano, S. Manyak, K. Parker, N. N. Sjak-Shie, R. Vescio, J. R.
Berenson. IkB/NFkB and chemo-resistance in multiple myeloma. VIII International Multiple
Myeloma Workshop Abstract Book: 129, 2001.
C. V. Altamirano, H. Ma, K. M. Parker, A. Glowalla, A. Mikail, N. N. Sjak-Shie, R.
A. Vescio, and J. R. Berenson. RANKL is expressed in malignant multiple myeloma (MM) cell
lines. Blood, Vol. 96, Suppl.1: 365a, 2000.
N. N. Sjak-Shie, G. Sulur, J. W. Said, R. A. Vescio and J. R. Berenson.
Angiogenesis and vascular endothelial growth factor expression correlate with the degree of
bone marrow involvement in multiple myeloma. VII International Multiple Myeloma Workshop
Abstract Book: 166, 1999.
N. N. Sjak-Shie, G. Sulur, J. W. Said, R. A. Vescio, and J. R. Berenson. Vascular
endothelial growth factor and angiogenesis in multiple myeloma. Blood, Vol. 94, Suppl. 1:
305b, 1999.
N. N. Sjak-Shie, A. S. Tsingotjidou, K. Zhang, R. A. Vescio, J. W. Said, J.
Lieberman, and J. R. Berenson. Development of a SCID-hu animal model that more closely
resembles human multiple myeloma. Blood, Vol. 94, Suppl. 1: 547a, 1999.
H. J. Ma, N. N. Sjak-Shie, R. A. Vescio, L. Zhang, A. Glowalla, M. Pold M. Beksac
and J. Berenson. Identification of a myeloma specific HHV-8 ORF65 gene. Blood, Vol. 94,
Suppl. 1: 485a, 1999.
N. N. Sjak-Shie, H. Ma, M. Der Danielian, R. A. Vescio, M. Kaminsky, A. Mikail, K.
Henick, G. Schiller, T. J. Moss, and J. R. Berenson. Incidence of HHV-8 infection in
patients with multiple myeloma and monoclonal gammopathy of undetermined significance.
Blood, Vol. 92, Suppl. 1: 97a, 1998.
N. N. Sjak-Shie, H. Ma, M. Der Danielian, R. A. Vescio, T. J. Moss, and J. R.
Berenson. Human herpesvirus-8 is not detectable in blood or bone marrow of patients with
solitary plasmacytomas. Blood, Vol. 92, Suppl. 1: 97a, 1998.
N. N. Sjak-Shie and E. M. Meyer. The cytoprotective effects of nicotine and/or
pilocarpine in cholinergically hypofunctional rat neocortex. Third IBRO World Congress of
Neuroscience, Vol. 1: 52, 1991.
N. N. Sjak-Shie, J. Burks, W. J. Millard, and E. M. Meyer. Long term nicotine
treatment in rats with bilateral nucleus basalis lesions. Society of Neuroscience
Abstracts, Part 1, Vol. 15: 679, 1989.
Book Chapters
N. N. Sjak-Shie and G. Schiller. Myeloproliferative syndromes. In: Chronic Leukemias and
Lymphomas: Pathogenesis and Management. G. Schiller (editor), Humana Press Inc., NJ. In
press.
N. N. Sjak-Shie, R. A. Vescio, and J. R. Berenson. The role of human herpesvirus-8
(HHV-8) in the pathogenesis of multiple myeloma. Clinics of North America. In:
Hematology/Oncology Clinics of North America: Monoclonal Gammopathies and Related Disorders,
R. Kyle and M. Gertz (editors), W. B. Saunders Company, PA, Vol. 13: 1159-1167, 1999.
N. N. Sjak-Shie, B. E. Hunter, and E. M. Meyer. Some novel actions of nicotine in
nucleus basalis lesioned rats and in hippocampal slices. In: Advances in Alzheimer Disease
Therapy: Cholinergic Basis for Alzheimer Therapy, E. Giacobini and R. Becker (editors),
Taylor and Francis, NY, 379-385, 1991.
N. N. Sjak-Shie, J. Burks, and E. M. Meyer. Long term actions of nicotinic
receptor stimulation in nucleus basalis lesioned rats: blockade of trans-synaptic cell loss.
In: Basic Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Disease, T.
Nagatsu, A. Fisher, and M. Yoshida (editors), Plenum Press, NY, Vol. 38B: 471-475, 1990.
J. J. Poulakos, G. W. Arendash, W. J. Millard, N. N. Sjak-Shie, E. M. Meyer.
Cholinergic-neuropeptide Y interactions in the rat cerebral cortex: toward a model for the
trans-synaptic effect of the cholinergic transmission. In: Advances in Behavioral Biology:
Novel Approaches to the Treatment of Alzheimer's Disease, E. M. Meyer, J. W. Simpkins, and
J. Yamamoto (editors), Plenum Press, NY, Vol. 36: 269-277, 1989.
Reviews (non-peer reviewed)
J. R. Berenson, N. N. Sjak-Shie, and R. A. Vescio. The role of human and viral
cytokines in the pathogenesis of multiple myeloma. Seminars in Cancer Biology, Vol. 10:
383-391, 2000.
N. N. Sjak-Shie, R. A. Vescio, and J. R. Berenson. Recent advances in multiple
myeloma. Curr. Opin. Hematol. Vol. 7: 241-246, 2000.
Clarithromycin adds to the efficacy of steroid therapy with/without thalidomide in
multiple myeloma: clinical and laboratory evidence. Presented at the VIII International
Multiple Myeloma Workshop, 2001.
The role of VEGF and angiogenesis in myeloma. Presented at the Mayo Clinic Judith
and George Goldman Symposium on Innovative Research in Multiple Myeloma, 2001
Advances in the treatment of myeloma and metastatic bone disease. Presented at the
Cedars-Sinai Medical Center Lecture Series for the Los Angeles community, 2000
The development of a novel SCID-hu animal model of multiple myeloma. Presented at
the UCLA-Jonsson Cancer Center Research Conference Series, 2000
Leukemias. Presented at the UCLA Oncology Program and Leukemia Society of America
Lecture Series for the Los Angeles community, 2000
Development of a SCID-hu animal model that more closely resembles human multiple
myeloma. Presented at the American Society of Hematology Annual Meeting, 1999
Angiogenesis and vascular endothelial growth factor expression correlate with the
degree of bone marrow involvement in multiple myeloma. Presented at the VII International
Multiple Myeloma Workshop, Stockholm, Sweden, 1999
A rare hematologic cause of polyarthritis. Presented at the American College of
Physicians Southern California Scientific Meeting, 1999
Incidence of HHV-8 infection in patients with multiple myeloma and monoclonal
gammopathy of undetermined significance. Presented at the American Society of Hematology
Annual Meeting, 1998
Human herpesvirus-8 is not detectable in blood or bone marrow of patients with
solitary plasmacytomas. Presented at the American Society of Hematology Annual Meeting,
1998
A case of abdominal pain and shock. Presented at the American College of
Physicians Florida Associates Scientific Meeting, 1996
The cytoprotective effects of nicotine and/or pilocarpine in cholinergically
hypofunctional rat neocortex. Presented at the International Brain Research Organization
World Congress of Neuroscience, 1991
Effects of long term nicotine treatment on nucleus basalis lesioned rats.
Presented at the Second Annual Suncoast Workshop on the Neurobiology of Aging, 1991
Cholinergic-peptide interactions in vivo: molecular to behavioral considerations.
Presented at the Miami Bio/Technology Winter Symposium on Advances in Gene Technology:
Molecular and Neuropharmacology, 1989
Long term nicotine treatment in rats with bilateral nucleus basalis lesions.
Presented at the Society of Neuroscience Conference, 1989
Cholinergic-peptide interactions in vivo: molecular to behavioral considerations.
Presented at the First Annual Suncoast Workshop on the Neurobiology of Aging, 1989
